Pyrroloquinoline Quinone and Mitochondria

Control of mitochondrial oxygen utilization and respiratory control is central to all aspects of normal growth and development.  In a broad setting, mitochondria are central to normal glucose, amino acid and fatty acid oxidation, reactive oxygen species (ROS), i.e., antioxidant modulation, and ATP production, particularly during exercise.  The mechanisms for mitochondrial regulation involve changes in the number of mitochondria per cell, the assembly and disassembly of mitochondria, control of transport of substances into and out of mitochondria, as well as control on the levels of activity of mitochondrial-related enzymes. Indeed, the importance of mitochondria to energy regulation cannot be understated. Mitochondria generate most of the cell’s supply of ATP, which is the major source of a cell’s potential chemical energy.

Moreover, in addition to supplying cellular energy, mitochondria are also important to cellular regulatory signaling, and the eventual programmed cell death (or apoptosis) and turnover of cells. The lifespan of all cells is directly linked to mitochondrial assembly and production. Such events can control new tissue growth, the response to infections, and nerve cell signaling and control.  In the average adult, between 50 and 70 billion cells turnover each day due to apoptosis pr programmed cell death.  In a year, this can amount to the proliferation and subsequent destruction of a mass of cells equal to one’s body weight!  When mitochondrial function at any level is compromised there can be a number of metabolic and health-related metabolic consequences.  Examples are a decline in mitochondrial oxidative efficiency, which is thought to be a major underlying feature of the metabolic syndromes that can lead to increased blood pressure and lipid levels, poorer responses to inflammation and, when targeted and severe, neurological disorders, such as Parkinson’s disease and Alzheimer’s dementia.


John Black

I suffer from Chronic Fatigue Syndrome due to a mitochondrial disorder. About 50 – 60 % of all my mitochondria are destroyed. Do you recommend PQQ to get new functioning mitochondria to recover from Chronic Fatigue Syndrome? What dose per day do you recommend? Are there any side effects from pyrroloquinoline quinone?

Douglass Genthner

What might the effects of PQQ be on the telomeres? I have been taking 20 mg of pyrroloquinoline quinone along with 300 mg of ubiquinol daily for about two months. As yet I have not noticed any effects, however I am age 82. Would perhaps it take me months longer than a much younger person to notice any benefits from PQQ? Thanks, Doug

Michael Rucker

Hi Doug, great question, so we tried to answer it the best we can for you by writing the Telomeres and Pyrroloquinoline Quinone post specifically to get you more information. If you have any further questions, please post them.

Anthony Juszczyk

I personally do John, but then again I’m not a doctor. From a personal standpoint and from what I’ve been reading I have heard that it does in fact have an impact on the amount of mitochondria. I have also read that it is safe to take up to 60mg. The decision is up to you, but I will be taking 20mg in the future in order to get an extra energy boost.

[MODERATOR NOTE: There currently is no peer-reviewed study indicating that 60mg of PQQ a day is safe. Therefore, with the exception of user posts (like this one), you will not see it advocated to take more than 20mg from this PQQ website.]

Barbara Vollick

My girlfriend has mitochondrial myopathy. Will this help? Thanks!

Michael Rucker

Hi Barbara, there are a number of different mitochondrial myopathies, all with different mechanisms. The short answer is that trying PQQ is always an option, but at this point it may only be a “shot in the dark”. For example, resveratrol in animal models protects against peripheral deficits of Huntington’s disease, but a search for resveratrol and mitochondrial myopathies does not indicate that much work has been done addressing such questions. There is now 100s of papers on resveratrol. Given that both resveratrol and PQQ seem to work by related mechanisms, we did the search with the hope of finding something that may be useful. Regrettably, such information is not available at this time on resveratrol or pyrroloquinoline quinone.

Mike G

Hi, I have been taking PQQ for a month now at 10mg a day, along with CoQ10, resveratrol and l- carthinine (which I have been taking since 1990). I have noticed a drop in blood pressure, increased stamina, and it has also made me very calm. I am a bodybuilder, 53 yrs old, and can work out without getting tired for hours! I recommend this combo to anyone.

Gladys Correa

Great information site about pyrroloquinoline quinone. Question: Is PQQ good at recovering part of lost memory. Thanks for your help. -Gladys